Challenges in Standardizing THCâCOOH Reference Materials and Calibrators
July 30, 2025, 1:44 p.m.
The challenges in standardizing THC‐COOH reference materials and calibrators have increasingly caught the attention of scientists, regulators, and industry experts alike. This definitive guide explores the intricate issues surrounding these materials and the calibrators used to measure levels of .…
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Analytical Techniques for Quantifying THCâCOOH (GCâMS, LCâMS/MS)
July 30, 2025, 1:44 p.m.
The field of cannabis testing has evolved considerably over the last decade, driven by the increasing need for accurate and reliable quantification methods of cannabinoids and their metabolites. Researchers and industry professionals now demand robust analytical techniques to ensure consumer safe.…
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Historical Development of THCâCOOH Testing Methods and Protocols
July 30, 2025, 1:44 p.m.
The historical development of THC–COOH testing methods and protocols in the cannabis space presents an intriguing narrative of scientific discovery, regulatory evolution, and technological advancement. Early research into cannabinoids laid a crucial foundation for the sophisticated testing method.…
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Pharmacodynamic Inactivity of THCâCOOH: Receptor Binding Studies
July 30, 2025, 1:44 p.m.
The study of cannabis pharmacology has always been complex, and one of the most intriguing aspects is the metabolism of Δ9-tetrahydrocannabinol (THC) and its resultant metabolites. Recent attention has focused on THC-COOH, a major inactive metabolite, which appears to exhibit pharmacodynamic inac.…
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Modeling THCâCOOH Pharmacokinetics: Population PK Approaches
July 30, 2025, 1:44 p.m.
The field of cannabis research has grown exponentially in recent years, and with it, the importance of understanding the pharmacokinetics of its key metabolites. THC‐COOH is a primary metabolite of THC, and modeling its behavior in the body has become critical for both clinical and forensic appli.…
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Metabolic Pathway: Conversion from THC to THCâCOOH via CYP450
July 30, 2025, 1:44 p.m.
The metabolic pathway that converts THC to THC‐COOH via the CYP450 enzyme system is a fascinating and complex process that lies at the heart of cannabis pharmacology. This process is central to understanding both the therapeutic impacts of cannabis and the interpretation of drug tests, as THC‐COO.…
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THCâCOOH Glucuronidation Pathways and Enzyme Activity
July 30, 2025, 1:44 p.m.
THC‐COOH glucuronidation represents a pivotal process in the metabolism of cannabis constituents, specifically transforming the primary metabolite of THC into water-soluble forms for excretion. This biochemical modification is essential for detoxification and clearance, allowing the body to effec.…
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Enzymatic Glucuronidation of THCâCOOH: UGT Isoforms Involved
July 30, 2025, 1:44 p.m.
Enzymatic glucuronidation of THC–COOH is a crucial pathway in the metabolism of cannabinoids, especially the major psychoactive constituent of cannabis, Δ9-THC. In this process, uridine diphospho-glucuronosyltransferase (UGT) enzymes attach glucuronic acid to THC–COOH, aiding its elimination from.…
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Impact of Liver Function and Genetic Polymorphisms on THCâCOOH Metabolism
July 30, 2025, 1:44 p.m.
The metabolism of THC-COOH, a primary metabolite of the psychoactive cannabinoid THC, represents a critical juncture between cannabis use and its clinical, forensic, and pharmacological outcomes. Researchers and clinicians alike have become increasingly intrigued by how intrinsic factors such as .…
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